Oridonin, an active component isolated from Rabdosia rubescences, has been reported to have antitumor effects.
1: Zhang JF, Liu JJ, Liu PQ, Lin DJ, Li XD, Chen GH. Related Articles, Links
Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells.
Hepatol Res. 2006 Apr 23; [Epub ahead of print]
PMID: 16638644 [PubMed - as supplied by publisher]
2: Lu Y, Sun C, Pan Y. Related Articles, Links
Short communication isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography.
J Sep Sci. 2006 Feb;29(2):314-8.
PMID: 16524109 [PubMed - in process]
3: Liu YQ, You S, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
[Oridonin induced U937 cell apoptosis through ERK pathway]
Zhongguo Zhong Yao Za Zhi. 2005 Dec;30(23):1856-9. Chinese.
PMID: 16499027 [PubMed - in process]
4: Liu JJ, Huang RW, Lin DJ, Wu XY, Peng J, Pan XL, Lin Q, Hou M, Zhang MH, Chen F. Related Articles, Links
Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action.
Am J Hematol. 2006 Feb;81(2):86-94.
PMID: 16432862 [PubMed - indexed for MEDLINE]
5: Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death.
Acta Med Okayama. 2005 Dec;59(6):261-70.
PMID: 16418769 [PubMed - indexed for MEDLINE]
6: Liu YQ, You S, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells.
Int Immunopharmacol. 2006 Feb;6(2):260-8. Epub 2005 Sep 23.
PMID: 16399631 [PubMed - indexed for MEDLINE]
7: Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis.
Biol Pharm Bull. 2005 Nov;28(11):2068-74.
PMID: 16272691 [PubMed - indexed for MEDLINE]
8: Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL, Wu JM. Related Articles, Links
Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.
Biochem Biophys Res Commun. 2005 Nov 11;337(1):224-31.
PMID: 16176802 [PubMed - indexed for MEDLINE]
9: Ren KK, Wang HZ, Xie LP, Chen DW, Liu X, Sun J, Nie YC, Zhang RQ. Related Articles, Links
The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells.
J Ethnopharmacol. 2006 Jan 16;103(2):176-80. Epub 2005 Oct 5.
PMID: 16169170 [PubMed - indexed for MEDLINE]
10: Zhang DR, Ren TC, Lou HX, Xing J. Related Articles, Links
[The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles]
Yao Xue Xue Bao. 2005 Jun;40(6):573-6. Chinese.
PMID: 16144328 [PubMed - in process]
11: Bai SP, Wei QY, Jin XL, Wu QX, Yang L. Related Articles, Links
Two novel ent-kauranoid diterpenoids from Isodon japonica leaves.
Planta Med. 2005 Aug;71(8):764-9.
PMID: 16142643 [PubMed - indexed for MEDLINE]
12: Liu YQ, You S, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.
J Pharmacol Sci. 2005 Aug;98(4):361-71. Epub 2005 Jul 29.
PMID: 16079470 [PubMed - indexed for MEDLINE]
13: Liu J, Huang R, Lin D, Wu X, Peng J, Lin Q, Pan X, Zhang M, Hou M, Chen F. Related Articles, Links
Apoptotic effect of oridonin on NB4 cells and its mechanism.
Leuk Lymphoma. 2005 Apr;46(4):593-7.
PMID: 16019488 [PubMed - indexed for MEDLINE]
14: Liu JJ, Huang RW, Lin DJ, Wu XY, Peng J, Pan XL, Song YQ, Lin Q, Hou M, Wang DN, Chen F, Zhang MH. Related Articles, Links
Oridonin-induced apoptosis in leukemia K562 cells and its mechanism.
Neoplasma. 2005;52(3):225-30.
PMID: 15875084 [PubMed - indexed for MEDLINE]
15: Leung CH, Grill SP, Lam W, Han QB, Sun HD, Cheng YC. Related Articles, Links
Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens.
Mol Pharmacol. 2005 Aug;68(2):286-97. Epub 2005 May 4.
PMID: 15872117 [PubMed - indexed for MEDLINE]
16: Ikezoe T, Yang Y, Bandobashi K, Saito T, Takemoto S, Machida H, Togitani K, Koeffler HP, Taguchi H. Related Articles, Links
Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.
Mol Cancer Ther. 2005 Apr;4(4):578-86.
PMID: 15827331 [PubMed - indexed for MEDLINE]
17: Liu YQ, You S, Zhang CL, Tashiro S, Onodera S, Ikejima T. Related Articles, Links
Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells.
Biol Pharm Bull. 2005 Mar;28(3):461-7.
PMID: 15744069 [PubMed - indexed for MEDLINE]
18: Chen S, Gao J, Halicka HD, Huang X, Traganos F, Darzynkiewicz Z. Related Articles, Links
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage.
Int J Oncol. 2005 Mar;26(3):579-88.
PMID: 15703811 [PubMed - indexed for MEDLINE]
19: Li RF, Wang QD. Related Articles, Links
[Regulation of telomerase activity and cell cycle of K562 cells by oridonin]
Yao Xue Xue Bao. 2004 Nov;39(11):865-8. Chinese.
PMID: 15696923 [PubMed - indexed for MEDLINE]
20: Han QB, Li RT, Li ML, Mou YK, Tian QE, Li SW, Sun HD. Related Articles, Links
Ent-kauranoids from Isodon rubescens var. taihangensis.
J Asian Nat Prod Res. 2005 Feb;7(1):31-6.
PMID: 15621599 [PubMed - indexed for MEDLINE]
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